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What happens to progesterone
during perimenopause?
Progesterone is a hormone that plays an important role in the second half of the menstrual cycle.
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After ovulation, it is produced by the ovaries and helps prepare the uterine lining for possible pregnancy. It also has effects on sleep and mood, and helps balance some of the effects of oestrogen.
During perimenopause, progesterone levels often change earlier and more consistently than other hormones.
Why progesterone production decreases in perimenopause
Progesterone is produced after ovulation. As ovulation becomes less frequent during perimenopause, overall progesterone levels tend to decrease.
How fewer ovulations reduce progesterone
Not every cycle during perimenopause includes ovulation. When ovulation does not occur, progesterone is not produced in the usual way.
How falling progesterone affects hormone balance
Progesterone helps balance the body as oestrogen fluctuations begin. As progesterone levels fall, this balance can shift, which may influence how the body responds to hormonal changes.
Progesterone declines before other hormones
Progesterone is often the first hormone to show a clear pattern of decline during perimenopause. This can happen even while other hormones are still fluctuating.
How progesterone changes affect symptoms
Changes in progesterone can contribute to symptoms such as insomnia, increased anxiety and feeling less settled during the second half of the cycle.
When to see a doctor
If you are experiencing symptoms that may be linked to progesterone changes, or if they are affecting your wellbeing, a perimenopause consultation can provide clarity about your treatment options.
Key points
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Progesterone levels tend to decrease during perimenopause.
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This is linked to fewer ovulatory cycles.
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Progesterone is only produced after ovulation.
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It plays a role in balancing other hormones.
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These changes contribute to common sleep, anxiety and mood changes throughout the transition.
Medically reviewed by Dr Susana Rodriguez, menopause clinician at ClaraSana Women’s Health, Perth.
Our content is based on up-to-date Australian guidelines & may differ from information on other sites.